Safety of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Intestinal absorption of nine drugs from oily vehicles and its relation to partition phenomena.
An in situ small intestine perfusion technique in the rat was used to study the absorption of drugs from oily vehicles. The affinity of the solute for the lipid phase played an important role with 2 triglycerides, tributyrin and tricaprylin; in these oils, absorption rate constants could be related either to entrapment of the drug or a concentration build-up at the intestinal surface, depending on the value of the partition coefficient On the contrary, no general rule could be established with Et laurate, which interacted in a specific manner with each drug tested. Theophylline absorption was strongly increase by this fatty acid ester as shown by luminal and blood level measurements. Thus, this model can be further refined by investigating the importance of the vehicle dose and bile flow to design a new dosage from with increased bioavailability in humans.
This literature about this compound(1028-33-7)Safety of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dionehas given us a lot of inspiration, and I hope that the research on this compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem