Quality Control of 2-Amino-5-chlorobenzaldehyde. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Iodothiophenes and Related Compounds as Coupling Partners in Copper-Mediated N-Arylation of Anilines. Author is Bouarfa, Salima; Bentabed-Ababsa, Ghenia; Erb, William; Picot, Laurent; Thiery, Valerie; Roisnel, Thierry; Dorcet, Vincent; Mongin, Florence.
N-Arylation of various 2-acylated anilines 2-NH2-5-R-C6H3C(O)R1 (R = H, Cl; R1 = H, Me, Ph) with different electron-rich heteroaryl iodides R2I (R2 = thiophen-2-yl, 1-benzothiophen-3-yl, furan-2-yl, etc.) was achieved by using activated copper and potassium carbonate in di-Bu ether at reflux. The reactivity of the different heteroaryl iodides and anilines employed was discussed and rationalized on the basis of their electronic features. Subsequent cyclization by aromatic electrophilic substitution easily took place in the case of C2-free (benzo)thienyl I (X = O, S) or C3-free (benzo)furyl derivatives, II affording original tri- and tetracycles. The antiproliferative activity of most of them was evaluated in A2058 melanoma cells and revealed four chlorinated tetracycles as effective growth inhibitors.
In addition to the literature in the link below, there is a lot of literature about this compound(2-Amino-5-chlorobenzaldehyde)Quality Control of 2-Amino-5-chlorobenzaldehyde, illustrating the importance and wide applicability of this compound(20028-53-9).
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem