Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 6-bromonicotinate, is researched, Molecular C7H6BrNO2, CAS is 26218-78-0, about [4+2] cycloaddition of trifluoromethyl ketimines with 2-alkenyl azaarenes through selective C-F bond cleavage of CF3.Reference of Methyl 6-bromonicotinate.
A new [4+2] cycloaddition of trifluoromethyl ketimines R1C6H4C(CF3)=NCH2C6H4R2 (R1 = H, 3-Me, 4-Br, 3-Cl, etc.; R2 = H, 3-F-4-Cl, 2-Me, 4-OMe, etc.) with 2-alkenyl azaarenes R3CH=CH2 (R3 = 5-cyano-3-methylpyridin-2-yl, 4-methylpyridin-2-yl, 6-chloroquinolin-2-yl, etc.) through selective C-F bond cleavage of CF3 has been developed. The reactions are promoted by 2,2,6,6-tetramethylpiperidine (TMP) under mild conditions to give cis-tetrahydropyridine I products in moderate yields. D. functional theory (DFT) calculations reveal that the in situ formed (E)-N-(2,2-difluoro-1-phenylvinyl)-1-phenylmethanimine is the key intermediate for the formation of cis-tetrahydropyridine products I which have the lowest energy among the four possible products.
There are many compounds similar to this compound(26218-78-0)Reference of Methyl 6-bromonicotinate. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem