Day: April 7, 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: N-((1S,2S)-2-Amino-1,2-diphenylethyl)-2,3,4,5,6-pentafluorobenzenesulfonamide, is researched, Molecular C20H15F5N2O2S, CAS is 313342-24-4, about Ir(III) complexes of diamine ligands for asymmetric ketone hydrogenation, the main research direction is arylalkanol asym preparation; arylketone asym hydrogenation iridium chiral diamine; chiral diaminepreparation iridium asym hydrogenation catalyst; diamine sulfonylation reductive amination.Quality Control of N-((1S,2S)-2-Amino-1,2-diphenylethyl)-2,3,4,5,6-pentafluorobenzenesulfonamide.

The use of a combination of IrCl3 with a series of ligands derived from the C2-sym. diamine diphenylethanediamine (DPEN) forms a catalyst capable of the asym. hydrogenation of ketones in up to 85% ee.

There are many compounds similar to this compound(313342-24-4)Quality Control of N-((1S,2S)-2-Amino-1,2-diphenylethyl)-2,3,4,5,6-pentafluorobenzenesulfonamide. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Borowiecki, Pawel; Zdun, Beata; Dranka, Maciej researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Recommanded Product: 1028-33-7.They published the article 《Chemoenzymatic enantioselective and stereo-convergent syntheses of lisofylline enantiomers via lipase-catalyzed kinetic resolution and optical inversion approach》 about this compound( cas:1028-33-7 ) in Molecular Catalysis. Keywords: Candida lipase lisofylline biocatalysts. We’ll tell you more about this compound (cas:1028-33-7).

Highly enantioselective enzymic kinetic resolution (EKR) of racemic lisofylline is presented for the first time. A comprehensive optimization of the key parameters of lipase-catalyzed transesterification of racemic lisofylline revealed that optimal biocatalytic system consisted of immobilized lipase type B from Candida antarctica (Chirazyme L-2, C-3) suspended in a mixture of 3 equiv of vinyl acetate as an acetyl donor and Et acetate as a solvent. Under optimal reaction conditions, the 1 g-scale (Chirazyme L-2, C-3)-catalyzed kinetic resolution of racemic lisofylline furnished both the EKR products in a homochiral form (>99 % ee) with the 50 % conv., and the highest possible enantioselectivity. The best results in terms of the reaction yields (47-50 %) and enantiomeric purity of the kinetically-resolved optically active products were achieved when the preparative-scale EKR was carried out for 2 h at 60 °C. In addition, stereoinversion of the less biol.-relevant (S)-lisofylline into its (R)-enantiomer was successfully achieved via acetolysis of the resp. optically pure (S)-mesylate by using 2 equiv of ceasium acetate and catalytic amount of 18-Crown-6 in dry toluene, followed by K2CO3-mediated methanolysis of (R)-acetate. The elaborated EKR methodol. together with enantioconvergent strategy provided a useful chemoenzymic protocol for the synthesis of complementary enantiomers of titled API. Moreover, we report on the first single-crystal X-ray diffraction (XRD) analyses performed for the synthesized lisofylline enantiomers. Insight into the source of CAL-B stereoselectivity toward racemic lisofylline was gained by mol. docking experiments In silico theor. predictions matched very well with exptl. results.

I hope my short article helps more people learn about this compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Recommanded Product: 1028-33-7. Apart from the compound(1028-33-7), you can read my other articles to know other related compounds.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Novel usage of 2-BTSO2CF2H for metal-free electrophilic difluoroalkanethiolation of indoles.

The electrophilic difluoromethylthiolation of indoles I [R = H, F, OMe; R1 = H, Me; R2 = H, Me; R3 = H, Me; R4 = H, Br, tetramethyl-1,3,2-dioxaborolan-2-yl, 1H-indazol-6-yl, etc.; R5 = H, dimethyl-1,2-oxazol-4-yl, 4-(dimethylamino)piperidin-1-yl, [(propan-2-yl)carbamoyl]oxidanyl, etc.; R6 = H; RR1 = -(CH2)3-] with 2-BTSO2CF2H is developed. In the presence of (EtO)2P(O)H and TMSCl, the reaction proceeded under mild conditions to give products I [R6 = (difluoromethyl)sulfanyl, (trifluoromethyl)sulfanyl, oxo(trifluoromethyl)sulfanyl, (chlorodifluoromethyl)sulfanyl] in modest to high yields. This is a new application of 2-BTSO2CF2H for electrophilic difluoromethylthiolation.

I hope my short article helps more people learn about this compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Reference of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate. Apart from the compound(51856-79-2), you can read my other articles to know other related compounds.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of N-((1S,2S)-2-Amino-1,2-diphenylethyl)-2,3,4,5,6-pentafluorobenzenesulfonamide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: N-((1S,2S)-2-Amino-1,2-diphenylethyl)-2,3,4,5,6-pentafluorobenzenesulfonamide, is researched, Molecular C20H15F5N2O2S, CAS is 313342-24-4, about Oxy-tethered Cp*Ir(III) complex as a competent catalyst for selective dehydrogenation from formic acid. Author is Nakamura, Hitomi; Yoshida, Minori; Matsunami, Asuka; Kuwata, Shigeki; Kayaki, Yoshihito.

A bifunctional tethered iridium catalyst containing a 1,2-diphenylethylenediamine framework was synthesized for the first time. The ethereal tether chain was easily constructed via the intramol. oxydefluorination of a perfluorophenylsulfonyl substituent by using a modified 1,2,3,4,5-pentamethylcyclopentadienyl ligand with a hydroxyalkyl chain. The conformationally constrained structure could hamper deactivation pathways in the catalytic hydrogen generation from formic acid, leading to advanced durability and complete conversion.

I hope my short article helps more people learn about this compound(N-((1S,2S)-2-Amino-1,2-diphenylethyl)-2,3,4,5,6-pentafluorobenzenesulfonamide)Quality Control of N-((1S,2S)-2-Amino-1,2-diphenylethyl)-2,3,4,5,6-pentafluorobenzenesulfonamide. Apart from the compound(313342-24-4), you can read my other articles to know other related compounds.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of (S)-Butan-2-ol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Chiral selectivity of porphyrin-ZnO nanoparticle conjugates. Author is Stefanelli, Manuela; Magna, Gabriele; Zurlo, Francesca; Caso, Federica M.; Di Bartolomeo, Elisabetta; Antonaroli, Simonetta; Venanzi, Mariano; Paolesse, Roberto; Di Natale, Corrado; Monti, Donato.

Recognition of enantiomers is one of the most arduous challenges in chem. sensor development. Although several chiral systems exist, their effective exploitation as the sensitive layer in chem. sensors is hampered by several practical implications that hinder stereoselective recognition in solid state. In this paper, the authors report a new methodol. to efficiently prepare chiral solid films, by using a hybrid material approach where chiral porphyrin derivatives are grafted onto zinc oxide nanoparticles. CD (CD) evidences that the solid-state film of the material retains supramol. chirality due to porphyrin interactions, besides an addnl. CD feature in correspondence of the absorbance of ZnO (375 nm), suggesting the induction of chirality in the underlying zinc oxide nanoparticles. The capability of hybrid material to detect and recognize vapors of enantiomer pairs was evaluated by fabricating gas sensors based on quartz microbalances. Chiral films of porphyrin on its own were used for comparison. The sensor based on functionalized nanostructures presented a remarkable stereoselectivity in the recognition of limonene enantiomers, whose ability to intercalate in the porphyrin layers makes this terpene an optimal chiral probe. The chiroptical and stereoselective properties of the hybrid material confirm that the use of porphyrin-capped ZnO nanostructures is a viable route for the formation of chiral selective surfaces.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yin, Lu; Miao, Teng-Fei; Cheng, Xiao-Xiao; Jiang, Zhi-Chao; Tong, Xia; Zhang, Wei; Zhao, Yue published the article 《Chiral Liquid Crystalline Elastomer for Twisting Motion without Preset Alignment of Mesogens》. Keywords: chiral liquid crystalline elastomer twisting motion preset alignment mesogen.They researched the compound: (S)-Butan-2-ol( cas:4221-99-2 ).Formula: C4H10O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4221-99-2) here.

A chiral liquid crystalline elastomer (CLCE) actuator is demonstrated. The solution-cast polydomain film of CLCE can twist upon order-disorder phase transition without any preset alignment of mesogens. The handedness of twisting is specific to the mol. chirality of the chiral dopant in the CLCE structure, while the degree of twisting, in terms of helical pitch and diameter, is sensitive to the aspect ratio and the thickness of the CLCE strip as well as the chiral dopant content. This phenomenon appears to stem from the local twisting forces and deformations of randomly oriented helical domains, which cannot cancel each other out due to the chirality and thus result in a macroscopic “”chiral”” force acting on the CLCE actuator. This finding reveals a materials design for preparing twisting LCE actuators.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Computed Properties of C7H6BrNO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Methyl 6-bromonicotinate, is researched, Molecular C7H6BrNO2, CAS is 26218-78-0, about Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions. Author is Zhang, Xitao; Feng, Xiujuan; Zhang, Haixia; Yamamoto, Yoshinori; Bao, Ming.

A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines I [R = H, 6-Me, 4-Br, etc.; R1 = Cl, Br] was described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation was operationally simple and exhibited high functional-group tolerance.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Sweet sorghum stalk liquefaction in supercritical methanol: Effects of operating conditions on product yields and molecular composition of soluble fraction, published in 2017-01-31, which mentions a compound: 51856-79-2, mainly applied to sweet sorghum stalk liquefaction supercritical methanol yield mol composition, Quality Control of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate.

Liquefaction of sweet sorghum stalk (SSS) in supercritical methanol was carried out under different conditions, including temperature, holding time, and SSS-to-methanol ratio. Each reaction mixture was filtrated to afford residue and bio-oil (BO, i.e., methanol-soluble portion). The optimal conditions were determined to be 300 °C and 30 min based on the BO yield and the maximum yield of BO is 40.5 wt% with higher heating value of 25.1 kJ g- 1. Low SSS-to-methanol ratio, i.e., either more methanol volume or less SSS dose, benefits the BO yield. According to gas chromatograph/mass spectrometric anal., the compounds detected in the BOs can be grouped into hydrocarbons, alcs., phenolic compounds (PCs), methoxybenzenes, ketones, esters, and others. Among them, PCs and esters are the most abundant. Guaiacols and alkylphenols are predominant PCs, which were mainly originated from the decomposition of lignin in SSS. Esters can be further classified into long-chain Me esters (LCMEs), short-chain Me esters (SCMEs), di-Me diesters, and polymethyl benzenepolycarboxylates. The variation of esters mainly relied on LCME and SCME change with varied reaction conditions.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Horner, J. Kenneth; Henry, David W. published the article 《Analogs of 3-amino-7-chloro-1,2,4-benzotriazine 1-oxide as antimalarial agents》. Keywords: antimalarial benzotriazine analogs; benzotriazine analogs antimalarial.They researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Reference of 2-Amino-5-chlorobenzaldehyde. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:20028-53-9) here.

A series of substituted 1,2,4-benzotriazines, quinazolines, quinoxalines, quinolines, and other related heterocycles were prepared for evaluation as antimalarial agents. Substituent patterns were chosen to provide maximum steric resemblance to 3-amino-7-chloro-1,2,4-benzotriazine 1-oxide (I), a known antimalarial. Slight favorable effects against exptl. Plasmodium berghei infections in mice were noted, but significant activity was not encountered. When assayed in vitro, five of the compounds were inhibitory to a series of eight other microorganisms.

I hope my short article helps more people learn about this compound(2-Amino-5-chlorobenzaldehyde)Reference of 2-Amino-5-chlorobenzaldehyde. Apart from the compound(20028-53-9), you can read my other articles to know other related compounds.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

COA of Formula: C7H6ClNO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors. Author is Jin, Xiao-Yan; Chen, Hao; Li, Dong-Dong; Li, A-Liang; Wang, Wen-Yan; Gu, Wen.

In this article, a series of novel quinoline derivatives of ursolic acid (UA) bearing hydrazide, oxadiazole, or thiadiazole moieties were designed, synthesized, and screened for their in vitro antiproliferative activities against three cancer cell lines (MDA-MB-231, HeLa, and SMMC-7721). A number of compounds showed significant activity against at least one cell line. Among them, compound exhibited the most potent activity against three cancer cell lines with IC50 values of 0.12 ± 0.01, 0.08 ± 0.01, and 0.34 ± 0.03 μM, resp. In particular, compound could induce the apoptosis of HeLa cells, arrest cell cycle at the G0/G1 phase, elevate intracellular reactive oxygen species level, and decrease mitochondrial membrane potential. In addition, compound could significantly inhibit MEK1 kinase activity and impede Ras/Raf/MEK/ERK transduction pathway. Therefore, compound may be a potential anticancer agent and a promising lead worthy of further investigation.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem