Reference of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Novel usage of 2-BTSO2CF2H for metal-free electrophilic difluoroalkanethiolation of indoles.
The electrophilic difluoromethylthiolation of indoles I [R = H, F, OMe; R1 = H, Me; R2 = H, Me; R3 = H, Me; R4 = H, Br, tetramethyl-1,3,2-dioxaborolan-2-yl, 1H-indazol-6-yl, etc.; R5 = H, dimethyl-1,2-oxazol-4-yl, 4-(dimethylamino)piperidin-1-yl, [(propan-2-yl)carbamoyl]oxidanyl, etc.; R6 = H; RR1 = -(CH2)3-] with 2-BTSO2CF2H is developed. In the presence of (EtO)2P(O)H and TMSCl, the reaction proceeded under mild conditions to give products I [R6 = (difluoromethyl)sulfanyl, (trifluoromethyl)sulfanyl, oxo(trifluoromethyl)sulfanyl, (chlorodifluoromethyl)sulfanyl] in modest to high yields. This is a new application of 2-BTSO2CF2H for electrophilic difluoromethylthiolation.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem