Horner, J. Kenneth; Henry, David W. published the article 《Analogs of 3-amino-7-chloro-1,2,4-benzotriazine 1-oxide as antimalarial agents》. Keywords: antimalarial benzotriazine analogs; benzotriazine analogs antimalarial.They researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Reference of 2-Amino-5-chlorobenzaldehyde. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:20028-53-9) here.
A series of substituted 1,2,4-benzotriazines, quinazolines, quinoxalines, quinolines, and other related heterocycles were prepared for evaluation as antimalarial agents. Substituent patterns were chosen to provide maximum steric resemblance to 3-amino-7-chloro-1,2,4-benzotriazine 1-oxide (I), a known antimalarial. Slight favorable effects against exptl. Plasmodium berghei infections in mice were noted, but significant activity was not encountered. When assayed in vitro, five of the compounds were inhibitory to a series of eight other microorganisms.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem