The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Does oxypentifylline reduce the intensity of acute graft-versus-host disease following allogeneic bone marrow transplantation?》. Authors are Ghosh, K; Hutchinson, R M.The article about the compound:1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dionecas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O).Formula: C13H20N4O2. Through the article, more information about this compound (cas:1028-33-7) is conveyed.
From 1988 to 1993, a retrospective analysis of the severity of acute graft-versus-host disease (GVHD) was carried out in two groups of patients undergoing allogeneic bone marrow transplantation for various haematological disorders. One group of 23 patients received oxypentifylline in a dose of 400 mg, 6 hourly, orally, day -10 to day +35 in addition to other standard management received by the control group of 20 patients. Acute GVHD was scored in each patient according to the Seattle criteria. Patients receiving oxypentifylline showed a lower GVHD score in each organ-specific area and this reached significance with the total GVHD score. A significantly smaller proportion of patients in the treatment group developed acute GVHD of grade 2 or more. It is concluded that oxypentifylline used in the present dosage reduces the intensity of acute GVHD following allogeneic bone marrow transplantation and is also well tolerated by the patient.
Compound(1028-33-7)Formula: C13H20N4O2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione), if you are interested, you can check out my other related articles.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem