In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis and in vitro anticancer activity of novel quinoline and oxadiazole derivatives of ursolic acid, published in 2017-09-01, which mentions a compound: 20028-53-9, Name is 2-Amino-5-chlorobenzaldehyde, Molecular C7H6ClNO, Electric Literature of C7H6ClNO.
A series of new quinoline derivatives of ursolic acid were designed and synthesized in an attempt to develop potential anticancer agents. The structures of these compounds were identified by 1H NMR, 13C NMR, IR and ESI-MS spectra anal. The target compounds were evaluated for their in vitro cytotoxicity against three human cancer cell lines (MDA-MB-231, HeLa and SMMC-7721). From the results, compounds I [R = H, OMe, Cl, F] displayed significant antitumor activity against three cancer cell lines. Especially, compound I [R = OMe] was found to be the most potent derivative with IC50 values of 0.61 ± 0.07, 0.36 ± 0.05, 12.49 ± 0.08 μM against MDA-MB-231, HeLa and SMMC-7721 cells, resp., stronger than pos. control etoposide. Furthermore, the Annexin V-FITC/PI dual staining assay revealed that compound I [R = OMe] could significantly induce the apoptosis of MDA-MB-231 cells in a dose-dependent manner. The cell cycle anal. also indicated that compound I [R = OMe] could cause cell cycle arrest of MDA-MB-231 cells at G0/G1 phase.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem