Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Quantitative structure-activity relations for the inhibition of guanine phosphoribosyltransferase from Escherichia coli.HPLC of Formula: 3066-84-0.
Electronic parameters calculated by HMO and Del Re methods and steric parameters calculated by the minimal steric difference (MTD) method are correlated with biol. activities for a series of 39 purinic derivatives tested as inhibitors of guanine phosphoribosyltransferase (GPRT) from E. coli. The best correlational equations thus obtained were tested on a series of 23 purinic derivatives for which inhibition constants are quoted as <3 by R. L. Miller et al. (1972). The correlational equations show that interactions between inhibitors and the active site of GPRT are controlled by both electronic and steric factors. I hope my short article helps more people learn about this compound(8-Bromoguanine)HPLC of Formula: 3066-84-0. Apart from the compound(3066-84-0), you can read my other articles to know other related compounds.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem