Quality Control of 2-Amino-5-chlorobenzaldehyde. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about I2-Catalyzed Aerobic Oxidative C(sp3)-H Amination/C-N Cleavage of Tertiary Amine: Synthesis of Quinazolines and Quinazolinones. Author is Yan, Yizhe; Xu, Ying; Niu, Bin; Xie, Huifang; Liu, Yanqi.
An iodine-catalyzed oxidative C(sp3)-H amination/C-N cleavage of tertiary amines conducted under an oxygen atm. has been developed and affords a route to quinazolines I [R1 = Ph, 4-MeC6H4, cyclopropyl, etc.; R2 = H, 6-Cl, 6-Br, etc.] and quinazolinones II [R3 = Ph, Bn, n-Bu, etc.] in good to excellent yields via a domino ring annulation. The method is metal-free, peroxide-free, and operationally simple to implement with a wide scope of substrates and represents a new avenue for multiple C-N bond formations.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem