The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The rearrangement of 2,4-dimethylthiazole 3-oxide with acetic anhydride》. Authors are Anderson, Hugh J.; Barnes, Douglas J.; Khan, Zahir M..The article about the compound:(2-Methylthiazol-4-yl)methanolcas:76632-23-0,SMILESS:OCC1=CSC(C)=N1).Name: (2-Methylthiazol-4-yl)methanol. Through the article, more information about this compound (cas:76632-23-0) is conveyed.
The rearrangement in Ac2O of 2,4-dimethylthiazole 3-oxide produced 2-acetoxymethyl-4-methylthiazole and 4-acetoxymethyl-2-methylthiazole in the ratio of about 4.5 to 1. The same type of rearrangement with 4-methylthiazole 3-oxide gave both 4-acetoxymethylthiazole and 2-acetoxy-4-methylthiazole, but in poor yields. The structure of the sulfate salt of 2,4-dimethylthiazole 3-oxide was established.
Compound(76632-23-0)Name: (2-Methylthiazol-4-yl)methanol received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2-Methylthiazol-4-yl)methanol), if you are interested, you can check out my other related articles.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem