Garel, Jean Pierre; Filliol, Dominique; Mandel, Paul published an article about the compound: 8-Bromoguanine( cas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O ).Application In Synthesis of 8-Bromoguanine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3066-84-0) through the article.
The behavior of 64 nucleic compounds (bases, nucleosides, nucleoside-mono-, -di-, and triphosphates) and 18 amino acids was studied in a saline solvent system used for counter-current distribution of transfer RNA based on 1.50M K phosphate pH 7.0, 2-methoxyethanol and 2-butoxyethanol. From the values of partition isotherms and partition coefficients K, measured in standard conditions at 20° and for 20% 2-butoxyethanol, it can be concluded that: (1) thiolation of bases decreases K, (2) phosphorylation of nucleosides accounts for neg., but additive effect on K, and (3) aliphatic lengthening of amino acids residues, N-alkylation, O-methylation, halogenation, C → N intracyclic substitution of bases, ribose → 3′-deoxyribose transformation increase K. The effect of these base or nucleoside substitutions is discussed and related to the mobility of tRNA separated by counter-current distribution.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem