Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Organic Chemistry called Phosphine Oxides (-POMe2) for Medicinal Chemistry: Synthesis, Properties, and Applications, Author is Stambirskyi, Maksym V.; Kostiuk, Tetiana; Sirobaba, Serhii I.; Rudnichenko, Alexander; Titikaiev, Dmytro L.; Dmytriv, Yurii V.; Kuznietsova, Halyna; Pishel, Iryna; Borysko, Petro; Mykhailiuk, Pavel K., which mentions a compound: 26218-78-0, SMILESS is C1=NC(=CC=C1C(=O)OC)Br, Molecular C7H6BrNO2, Computed Properties of C7H6BrNO2.
A general practical approach to hetero(aromatic) and aliphatic P(O)Me2-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me2. The P(O)Me2 substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biol. profile.
From this literature《Phosphine Oxides (-POMe2) for Medicinal Chemistry: Synthesis, Properties, and Applications》,we know some information about this compound(26218-78-0)Computed Properties of C7H6BrNO2, but this is not all information, there are many literatures related to this compound(26218-78-0).
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem