The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromoguanine( cas:3066-84-0 ) is researched.Computed Properties of C5H4BrN5O.Olaru, Niculae; Simon, Zeno published the article 《Electronic structure and reactivity indexes for a series of purine derivatives, inhibitors of guanine phosphoribosyltransferase from Escherichia coli》 about this compound( cas:3066-84-0 ) in Revue Roumaine de Chimie. Keywords: structure activity purine derivative guanine phosphoribosyltransferase; Escherichia guanine phosphoribosyltransferase inhibition purine structure; electron structure purine guanine transferase inhibition. Let’s learn more about this compound (cas:3066-84-0).
The reactivity indexes and electronic structure for a series of 62 purinic derivatives, tested as inhibitors of guanine phosphoribosyltransferase (GPRT) from E. coli, were calculated using HMO and Del Re methods. Some quant. structure activity relationships (QSAR) for a set of 13 compounds with similar steric structure are given. The correlational equations obtained show the importance of electronic control in the inhibition of GPRT.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem