The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-5-chlorobenzaldehyde(SMILESS: NC1=CC=C(Cl)C=C1C=O,cas:20028-53-9) is researched.Reference of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. The article 《Gold(I)-Catalyzed Unprecedented Rearrangement Reaction Between 2-Aminobenzaldehydes with Propargyl Amines: An Expedient Route to 3-Aminoquinolines》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:20028-53-9).
A gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amine was studied. The study provided, for the first time, direct access to 3-aminoquinolines in one step starting from readily available starting materials. Elegantly designed experiments were employed to unravel the mechanism of this unprecedented rearrangement, which are corroborated by DFT calculations
There is still a lot of research devoted to this compound(SMILES：NC1=CC=C(Cl)C=C1C=O)Application In Synthesis of 2-Amino-5-chlorobenzaldehyde, and with the development of science, more effects of this compound(20028-53-9) can be discovered.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem