The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 6-bromonicotinate( cas:26218-78-0 ) is researched.Reference of Methyl 6-bromonicotinate.Wagener, Tobias; Lueckemeier, Lukas; Daniliuc, Constantin G.; Glorius, Frank published the article 《Interrupted pyridine hydrogenation: Asymmetric synthesis of δ-lactams》 about this compound( cas:26218-78-0 ) in Angewandte Chemie, International Edition. Keywords: delta lactam preparation oxazolidinone substituted pyridine interrupted hydrogenation; asymmetric catalysis; heterogeneous catalysis; hydrogenation; lactams; nitrogen heterocycles. Let’s learn more about this compound (cas:26218-78-0).
Metal-catalyzed hydrogenation is an effective method to transform readily available arenes into saturated motifs, however, current hydrogenation strategies are limited to the formation of C-H and N-H bonds. The stepwise addition of hydrogen yields reactive unsaturated intermediates that are rapidly reduced. In contrast, the interruption of complete hydrogenation by further functionalization of unsaturated intermediates offers great potential for increasing chem. complexity in a single reaction step. Overcoming the tenet of full reduction in arene hydrogenation has been seldom demonstrated. In this work the authors report the synthesis of sought-after, enantioenriched δ-lactams from oxazolidinone-substituted pyridines and water by an interrupted hydrogenation mechanism.
From this literature《Interrupted pyridine hydrogenation: Asymmetric synthesis of δ-lactams》,we know some information about this compound(26218-78-0)Reference of Methyl 6-bromonicotinate, but this is not all information, there are many literatures related to this compound(26218-78-0).
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem