In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Irreversible enzyme inhibitors. LXXIII. Inhibitors of guanine deaminase. 1. Mode of binding of guanine, published in 1967, which mentions a compound: 3066-84-0, mainly applied to GUANINE BINDING GUANINE DEAMINASE; SUBSTRATE BINDING GUANINE DEAMINASE; BINDING GUANINE GUANINE DEAMINASE; GUANINE DEAMINASE GUANINE BINDING, HPLC of Formula: 3066-84-0.
cf. preceding abstract Investigation of guanine and 17 related compounds as substrates or inhibitors of guanine deaminase led to a suggested mode of binding of guanine. The 1- and 9-hydrogens of guanine are probably complexed to the enzyme as electron acceptors and the 6-oxo and 7-nitrogen are complexed as electron donors. It appears that the π cloud, as well as the 2-NH2 group of guanine do not complex to the enzyme. It is possible that the 3-nitrogen of guanine as an electron donor is complexed to the enzyme.
Compound(3066-84-0)HPLC of Formula: 3066-84-0 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(8-Bromoguanine), if you are interested, you can check out my other related articles.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem