Reference of 2-Amino-5-chlorobenzaldehyde. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Silver-Catalyzed Three-Component Coupling Reaction of Amines, 2-Isocyanobenzaldehydes, and 2,2,2-Trifluorodiazoethane and Synthesis of Trifluoromethyl-Substituted Indolo[1,2-c]quinazolines. Author is Meng, Xiang-He; Yang, Ming; Peng, Ju-Yin; Zhao, Yu-Long.
A silver-catalyzed three-component coupling reaction of amines RNH2 (R = t-Bu, cyclohexyl, naphthalen-1-yl, pyridin-3-yl, etc.), 2-isocyanobenzaldehydes 2-NC-4-R1-5-R2-C6H2CHO (R1 = H, Br; R2 = H, F, Cl; R1R2 = -OCH2O-), and 2,2,2-trifluorodiazoethane has been developed. This reaction provides an efficient method for the construction of CF3-containing dihydroquinazolines I. On the basis of this reaction, using trifluorodiazoethyl-substituted dihydroquinazolines I as synthons, trifluoromethyl-substituted indolo[1,2-c]quinazolines II [R3 = H, CF3; R4 = H, F, Cl, Me, OMe, N(CH3)2; R5 = H, CF3; R6 = H, Me] were prepared in high yields via a TBHP/KI-mediated sequential intramol. cyclization and aromatization process.
In some applications, this compound(20028-53-9)Reference of 2-Amino-5-chlorobenzaldehyde is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem