So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yan, Yizhe; Zhang, Yonghui; Feng, Chengtao; Zha, Zhenggen; Wang, Zhiyong researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Formula: C7H6ClNO.They published the article 《Selective iodine-catalyzed intermolecular oxidative amination of C(sp3)-H bonds with ortho-carbonyl-substituted anilines to give quinazolines》 about this compound( cas:20028-53-9 ) in Angewandte Chemie, International Edition. Keywords: quinazoline preparation; acyl aniline DMF oxidative amination iodine catalyst. We’ll tell you more about this compound (cas:20028-53-9).
An iodine-catalyzed oxidative amination of C(sp3)-H bonds adjacent to nitrogen or oxygen atoms for the synthesis of quinazolines from o-carbonyl-substituted anilines, ammonia and solvents, such as N-alkylamides, ethers, and alcs, is reported. A wide tolerance of various functional groups, lack of transition metals, and production of alc. and water as the only waste are te major merits of this method. A series of substituted quinazoline derivatives were obtained using this strategy.
In some applications, this compound(20028-53-9)Formula: C7H6ClNO is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem