The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Bromoguanine(SMILESS: NC(N1)=NC(NC(Br)=N2)=C2C1=O,cas:3066-84-0) is researched.Electric Literature of C10H10Cl2N2Pt. The article 《Effects of Site-Specific Guanine C8-Modifications on an Intramolecular DNA G-Quadruplex》 in relation to this compound, is published in Biophysical Journal. Let’s take a look at the latest research on this compound (cas:3066-84-0).
Understanding the fundamentals of G-quadruplex formation is important both for targeting G-quadruplexes formed by natural sequences and for engineering new G-quadruplexes with desired properties. Using a combination of exptl. and computational techniques, we have investigated the effects of site-specific substitution of a guanine with C8-modified guanine derivatives, including 8-bromo-guanine, 8-O-methyl-guanine, 8-amino-guanine, and 8-oxo-guanine, within a well-defined (3+1) human telomeric G-quadruplex platform. The effects of substitutions on the stability of the G-quadruplex were found to depend on the type and position of the modification among different guanines in the structure. An interesting modification-dependent NMR chem.-shift effect was observed across basepairing within a guanine tetrad. This effect was reproduced by ab initio quantum mech. computations, which showed that the observed variation in imino proton chem. shift is largely influenced by changes in hydrogen-bond geometry within the guanine tetrad.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem