The effect of the change of synthetic route on the product 51856-79-2

Here is just a brief introduction to this compound(51856-79-2)Electric Literature of C8H11NO2, more information about the compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate) is in the article, you can click the link below.

Maryanoff, Bruce E. published the article 《Reaction of dimethyl diazomalonate and ethyl 2-diazoacetoacetate with N-methylpyrrole》. Keywords: methylpyrrole alkylation regioselectivity diazomalonate diazoacetoacetate; pyrrole alkylation regioselectivity diazomalonate diazoacetoacetate.They researched the compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ).Electric Literature of C8H11NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:51856-79-2) here.

N2CH(CO2Me)2 (I) reacts with N-methylpyrrole (II), under metal “”catalysis””, to give pyrrole-malonate adducts III (R = R1 = COMe) and IV (R = R1 = COMe). Yields of adducts are particularly high with Cu(IPSAL)2, Cu(hfacac)2, and Rh2(OAc)4 as promoting agents. The regioselectivity for 2-position substitution is generally higher for I compared to N2CH2CO2Et; also, yields of adducts are generally better with I. N2CH(COMe)CO2Et reacts with II to furnish good yields of monoadduct, which is exclusively composed of the 2-position isomer III (R = COMe, R1 = CO2Et).

Here is just a brief introduction to this compound(51856-79-2)Electric Literature of C8H11NO2, more information about the compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate) is in the article, you can click the link below.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem