Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1028-33-7, is researched, Molecular C13H20N4O2, about Autoradiographic study of the distribution of 1-hexyl-3,7-dimethylxanthine-14C in mice, the main research direction is HEXYLXANTHINES METAB; XANTHINES METAB; DIMETHYLXANTHINES METAB; METAB DIMETHYLXANTHINES.Application of 1028-33-7.
Pregnant white mice were given 2 mg. of 1-hexyl-3,7-dimethylxanthine-14C (SK7-14C) dissolved in Me2SO in the tail vein, and sacrificed 5 and 20 min., 1, 4, 24, 48, and 96 hrs. after injection. Shortly after injection, the radioactivity accumulated in the brain but left it rather rapidly. Different parts of the eye showed a rather specific uptake of radioactivity. The lens of the fetus contained a higher level of radioactivity than that of the mother 3 days after injection. The walls of the large vessels had an affinity for SK7 or its metabolites, and it appears that SK7 passed the blood-brain barrier rather easily but penetrated the placental barrier rather poorly. The bone marrow concentrated the drug or its metabolites for a rather long time. The major excretion routes of the labeled substance (or substances) were the bile and urine.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem