The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ) is researched.Related Products of 51856-79-2.Youngman, Mark A.; Carson, John R.; Lee, Jung S.; Dax, Scott L.; Zhang, Sui-Po; Colburn, Ray W.; Stone, Dennis J.; Codd, Ellen E.; Jetter, Michele C. published the article 《Synthesis and structure-Activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists》 about this compound( cas:51856-79-2 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: methylquinolinyloxymethylphenyl aroylpyrrolylalkylamide preparation human bradykinin B2 receptor antagonist; quinolinyloxymethylphenyl aroylpyrrolylalkylamide preparation human bradykinin B2 receptor antagonist; pyrrolylalkylamide methylquinolinyloxymethylphenyl aroyl preparation human bradykinin B2 receptor antagonist; alkylamide methylquinolinyloxymethylphenyl aroylpyrrolyl preparation human bradykinin B2 receptor antagonist; bradykinin B2 receptor binding affinity aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation; antinociception aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation; structure activity bradykinin B2 receptor binding aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation. Let’s learn more about this compound (cas:51856-79-2).
The structure-activity relationships of a novel series of aroylpyrrole alkylamides I (R1 = R2 = R3 = Me, R4 = 4-NCC6H4, 3-pyridyl, 2-thienyl, etc.; R1 = Cl, R2 = Me, H, Et, etc., R3 = Me, Et, n-Bu, etc., R4 = 4-NCC6H4, 4-ClC6H4, 3-pyridyl, etc.; n = 1-2) prepared from 3-[(2-methyl-8-quinolinyl)oxymethyl]benzenamine derivatives, as potent selective bradykinin B2 receptor antagonists are described. Several members of this series display nanomolar affinity at the B2 receptor and show activity in an animal model of antinociception, such as I (R1 = Cl, R2 = R3 = Me, R4 = 6-chloro-3-pyridyl, n = 2).
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem