The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ) is researched.Application In Synthesis of 2-Amino-5-chlorobenzaldehyde.Zhang, Jintang; Zhu, Dapeng; Yu, Chenmin; Wan, Changfeng; Wang, Zhiyong published the article 《A Simple and Efficient Approach to the Synthesis of 2-Phenylquinazolines via sp3 C-H Functionalization》 about this compound( cas:20028-53-9 ) in Organic Letters. Keywords: phenylquinazoline preparation. Let’s learn more about this compound (cas:20028-53-9).
A facile and novel approach to the synthesis of 2-phenylquinazolines was developed via a tandem reaction following sp3 C-H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.
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Reference:
Tetrahydrofuran – Wikipedia,
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