Extended knowledge of 3066-84-0

Compound(3066-84-0)Category: tetrahydrofurans received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(8-Bromoguanine), if you are interested, you can check out my other related articles.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Regulation of One-Electron Oxidation Rate of Guanine by Base Pairing with Cytosine Derivatives, published in 2002-04-10, which mentions a compound: 3066-84-0, Name is 8-Bromoguanine, Molecular C5H4BrN5O, Category: tetrahydrofurans.

Effects of base pairing on the one-electron oxidation rate of guanine derivatives, guanine, 8-bromoguanine, and 8-oxo-7,8-dihydroguanine have been studied. The one-electron oxidation rate of guanine derivatives was determined by triplet-quenching experiments, using N,N’-dibutylnaphthaldiimide (NDI) in the triplet excited state (3NDI*) and fullerene (C60) in the triplet excited state (3C60*) as oxidants. In all three guanine derivatives studied here, acceleration of the one-electron oxidation was observed upon hydrogen bonding with cytosine, which demonstrates lowering of the oxidation potential of guanine derivatives by base pairing with cytosine. When a Me or bromo group was introduced to the C5 position of cytosine, acceleration or suppression of the one-electron oxidation relative to the guanine:cytosine base pair was observed, resp. The results demonstrate that the one-electron oxidation rate of guanine in DNA can be regulated by introducing a substituent on base pairing cytosine.

Compound(3066-84-0)Category: tetrahydrofurans received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(8-Bromoguanine), if you are interested, you can check out my other related articles.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem