Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 26218-78-0, is researched, Molecular C7H6BrNO2, about Synthesis and biological activities of new HMG-COA synthase inhibitors: 2-oxetanones with a side chain containing biphenyl, terphenyl or phenylpyridine, the main research direction is HMGCoA synthase inhibition 1233A analog; oxetanone isostere preparation HMGCoA synthase inhibition.SDS of cas: 26218-78-0.
A series of 1233A analogs containing biphenylyl, terphenylyl or phenylpyridyl groups in their side chain were synthesized and tested for the inhibitory activities against 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase and inhibition of cholesterol biosynthesis in the mouse liver. The compounds with an oxetane, cyclobutanone or γ-butyrolactone ring as isosteres of a 2-oxetanone ring were entirely inactive. Among synthetic analogs, anti-4-[3-[2-(5-isopropyl-2-pyridyl)ethyl]phenyl]ethyl-3-hydroxymethyl-2-oxetanone was most active in vitro. The structure-activity relationships on the transformations of 2-oxetanone and its side chain were obtained.
Here is just a brief introduction to this compound(26218-78-0)SDS of cas: 26218-78-0, more information about the compound(Methyl 6-bromonicotinate) is in the article, you can click the link below.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem