Day: March 31, 2022

Nakabayashi, Kazuhiro; Fujita, Karin published an article about the compound: (S)-Butan-2-ol( cas:4221-99-2,SMILESS:C[C@H](O)CC ).COA of Formula: C4H10O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4221-99-2) through the article.

A series of novel poly(m-phenylene)s with terthiophene and/or chiral side chains have been developed to investigate the correlation between poly(m-phenylene) polymer structure and self-assembly behaviors. As a result of CD spectroscopy, a poly(m-phenylene) that alternately had terthiophene and chiral side chains exhibited the clear Cotton effect in THF, THF/methanol, and THF/acetonitrile conditions, indicating that the defined nanostructure was successfully formed by efficiently using the two interactions between side chains even in the good solvent condition. On the other hand, poly(m-phenylene)s with an irregularly sequence of terthiophene and chiral side chains did not have a capability to form the nanostructure regardless of solvent condition. These results demonstrated that an efficient usage of side chain interactions based on an alternating polymer structure was important for the formation of self-assembled nanostructure in poly(m-phenylene)s.

Here is just a brief introduction to this compound(4221-99-2)COA of Formula: C4H10O, more information about the compound((S)-Butan-2-ol) is in the article, you can click the link below.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 26218-78-0, is researched, Molecular C7H6BrNO2, about Synthesis and biological activities of new HMG-COA synthase inhibitors: 2-oxetanones with a side chain containing biphenyl, terphenyl or phenylpyridine, the main research direction is HMGCoA synthase inhibition 1233A analog; oxetanone isostere preparation HMGCoA synthase inhibition.SDS of cas: 26218-78-0.

A series of 1233A analogs containing biphenylyl, terphenylyl or phenylpyridyl groups in their side chain were synthesized and tested for the inhibitory activities against 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase and inhibition of cholesterol biosynthesis in the mouse liver. The compounds with an oxetane, cyclobutanone or γ-butyrolactone ring as isosteres of a 2-oxetanone ring were entirely inactive. Among synthetic analogs, anti-4-[3-[2-(5-isopropyl-2-pyridyl)ethyl]phenyl]ethyl-3-hydroxymethyl-2-oxetanone was most active in vitro. The structure-activity relationships on the transformations of 2-oxetanone and its side chain were obtained.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 20028-53-9, is researched, Molecular C7H6ClNO, about Highly Efficient and Selective Catalytic Synthesis of Quinolines Involving Transition-Metal-Doped Carbon Aerogels, the main research direction is aminobenzaldehyde Et acetoacetate Friedlaender reaction aerogel; quinole preparation; transition metal doped carbon aerogel preparation Friedlaender reaction nanocatalyst.Formula: C7H6ClNO.

Carbon aerogels doped with transition metals are found to be efficient and reusable catalysts involved in the selective synthesis of quinolines. Interestingly, we report herein the first aldol-based reactions, particularly the Friedlaender reaction, catalyzed by zero-valent metal nanoparticles, the activity of which is mainly related with the nature of the metal. Co0- and Cu0-doped aerogels resulted in the most active catalysts. Resorcinol-formaldehyde Cu-doped and steam-activated (RFCuS) aerogel represents an alternative nanocatalyst to the metal-organic framework CuBTC showing similar reactivity but superior thermal and chem. stability. The unusual reactivity observed could be explained by the in situ generation of the Co0-CoII catalytic system formed in the activation of Et acetoacetate.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Maryanoff, Bruce E. published the article 《Reaction of dimethyl diazomalonate and ethyl 2-diazoacetoacetate with N-methylpyrrole》. Keywords: methylpyrrole alkylation regioselectivity diazomalonate diazoacetoacetate; pyrrole alkylation regioselectivity diazomalonate diazoacetoacetate.They researched the compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ).Electric Literature of C8H11NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:51856-79-2) here.

N2CH(CO2Me)2 (I) reacts with N-methylpyrrole (II), under metal “”catalysis””, to give pyrrole-malonate adducts III (R = R1 = COMe) and IV (R = R1 = COMe). Yields of adducts are particularly high with Cu(IPSAL)2, Cu(hfacac)2, and Rh2(OAc)4 as promoting agents. The regioselectivity for 2-position substitution is generally higher for I compared to N2CH2CO2Et; also, yields of adducts are generally better with I. N2CH(COMe)CO2Et reacts with II to furnish good yields of monoadduct, which is exclusively composed of the 2-position isomer III (R = COMe, R1 = CO2Et).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Identification of purines on paper chromatograms, the main research direction is CAFFEINE; PURINES.Quality Control of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.

Caffeine (10-20 γ) is detected on paper chromatograms by exposing the spot to Br vapor after locating it under ultraviolet light. The spot is steamed briefly and heated at 110-120°. The rose-pink color which develops is turned reddish purple by exposure to NH3. The Rf value differentiates caffeine from the other compounds giving the reaction: theobromine, theophylline, 1-n-hexyltheobromine, proxyphylline, etophylate, and diprophylline.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Induction, fixation and recovery of self-organized helical superstructures in achiral liquid crystalline polymer, published in 2021, which mentions a compound: 4221-99-2, Name is (S)-Butan-2-ol, Molecular C4H10O, Computed Properties of C4H10O.

The fixation, storage and self-recovery of chiral information in superstructures constructed by weak noncovalent bonds remain a big challenge in nature. Here, we describe a novel self-assembled system where the mol. chirality can be transferred and further stored into a helical superstructure. Based on achiral liquid crystalline polymers (LCPs), the twist between azobenzene (Azo) units in polymer side chains can be switched by the configuration or alkyl chain length of the introduced chiral dopant. Furthermore, the crosslinking strategy of polymer side chains was adopted to allow permanent memory of the induced helical superstructure after complete removal of the chiral dopant. Although the helical superstructure was temporarily destroyed by UV light irradiation, the stored chiral information enabled self-recovery of the previous helical chirality, without the need for any pre-existing chiral source. The chiral switching in the absence of chiral source is unprecedented and opens a new window for the design and application of chiral materials.

Here is just a brief introduction to this compound(4221-99-2)Computed Properties of C4H10O, more information about the compound((S)-Butan-2-ol) is in the article, you can click the link below.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1028-33-7, is researched, Molecular C13H20N4O2, about Autoradiographic study of the distribution of 1-hexyl-3,7-dimethylxanthine-14C in mice, the main research direction is HEXYLXANTHINES METAB; XANTHINES METAB; DIMETHYLXANTHINES METAB; METAB DIMETHYLXANTHINES.Application of 1028-33-7.

Pregnant white mice were given 2 mg. of 1-hexyl-3,7-dimethylxanthine-14C (SK7-14C) dissolved in Me2SO in the tail vein, and sacrificed 5 and 20 min., 1, 4, 24, 48, and 96 hrs. after injection. Shortly after injection, the radioactivity accumulated in the brain but left it rather rapidly. Different parts of the eye showed a rather specific uptake of radioactivity. The lens of the fetus contained a higher level of radioactivity than that of the mother 3 days after injection. The walls of the large vessels had an affinity for SK7 or its metabolites, and it appears that SK7 passed the blood-brain barrier rather easily but penetrated the placental barrier rather poorly. The bone marrow concentrated the drug or its metabolites for a rather long time. The major excretion routes of the labeled substance (or substances) were the bile and urine.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ) is researched.Related Products of 51856-79-2.Youngman, Mark A.; Carson, John R.; Lee, Jung S.; Dax, Scott L.; Zhang, Sui-Po; Colburn, Ray W.; Stone, Dennis J.; Codd, Ellen E.; Jetter, Michele C. published the article 《Synthesis and structure-Activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists》 about this compound( cas:51856-79-2 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: methylquinolinyloxymethylphenyl aroylpyrrolylalkylamide preparation human bradykinin B2 receptor antagonist; quinolinyloxymethylphenyl aroylpyrrolylalkylamide preparation human bradykinin B2 receptor antagonist; pyrrolylalkylamide methylquinolinyloxymethylphenyl aroyl preparation human bradykinin B2 receptor antagonist; alkylamide methylquinolinyloxymethylphenyl aroylpyrrolyl preparation human bradykinin B2 receptor antagonist; bradykinin B2 receptor binding affinity aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation; antinociception aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation; structure activity bradykinin B2 receptor binding aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation. Let’s learn more about this compound (cas:51856-79-2).

The structure-activity relationships of a novel series of aroylpyrrole alkylamides I (R1 = R2 = R3 = Me, R4 = 4-NCC6H4, 3-pyridyl, 2-thienyl, etc.; R1 = Cl, R2 = Me, H, Et, etc., R3 = Me, Et, n-Bu, etc., R4 = 4-NCC6H4, 4-ClC6H4, 3-pyridyl, etc.; n = 1-2) prepared from 3-[(2-methyl-8-quinolinyl)oxymethyl]benzenamine derivatives, as potent selective bradykinin B2 receptor antagonists are described. Several members of this series display nanomolar affinity at the B2 receptor and show activity in an animal model of antinociception, such as I (R1 = Cl, R2 = R3 = Me, R4 = 6-chloro-3-pyridyl, n = 2).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of Investigative Dermatology called Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: Evidence for mediation by nuclear factor 1 down-regulation, Author is Duncan, Matthew R.; Hasan, Anthony; Berman, Brian, which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Electric Literature of C13H20N4O2.

Pentoxifylline (PTX) is a methylxanthine that exhibits multiple biol. activities, including the inhibition of collagen synthesis by dermal fibroblasts. Because some PTX activities have recently been linked to transcription factor-mediated regulation of gene transcription, we have investigated if PTX acts to inhibit collagen synthesis at a transcriptional locus by measuring procollagen mRNA levels and by assaying for the presence of an activator of procollagen gene promoters, nuclear factor (NF)-1. The effects of another methylxanthine, pentifylline (PTF), shown herein to be a ten-fold more potent inhibitor of collagen synthesis than PTX, and interferon-α, -β, and -γ were studied in parallel. Anal. of extracellular protein and RNA from 48-h-treated fibroblasts showed that PTX, PTF, and interferons decreased α1(I), α2(I), and α1(III) procollagens by reducing the steady-state levels of the corresponding procollagen mRNA transcripts. Reduction of procollagen mRNA levels appeared to be dependent on new protein synthesis, as it was prevented by treatment with cycloheximide. Assay for the presence of nuclear NF-1 by gel mobility shift anal. showed that extracts from interferon, PTX, and PTF-treated fibroblasts lacked proteins recognizing the consensus DNA binding sequence for NF-1. Taken together, these observations suggest interferons and methylxanthines may inhibit fibroblast collagen synthesis by a common mechanism requiring new protein synthesis that suppresses procollagen gene transcription through down-regulation of NF-1.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Low spin ferric hemoglobin complexes》. Authors are Harris, Gilda.The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).Electric Literature of C5H4BrN5O. Through the article, more information about this compound (cas:3066-84-0) is conveyed.

A calculation has been made of the energy eigenfunctions and eigenvalues of low-spin ferric ion in complexes with a strong cubic crystal field including the effects of tetragonal and rhombic distortions and of spin-orbit coupling among the ground state components and with excited states. Using the resultant, spin-orbit coupled eigenfunctions as a basis set, the magnetic susceptibility, the components of magnetic field energy, and the lattice and valence contributions to an elec. field gradient at the iron nucleus were all calculated as a function of rhombic, tetragonal, and spin-orbit coupling strength used as parameters: R, u, and δ. All of the calculated results agree reasonably well with exptl. for the values of parameters R = 1000 cm.-1 u = 2000 cm.-1, and the free ion value δ= 420 cm.-1 These values of parameters were selected for the excellent fit they gave of the calculated values of gx, gy, and gz compared with the exptl. ones obtained from single crystal ESR of ferriHb azide. With them, a value of 2.29 μB was calculated for the effective magnetic moment compared to the exptl. value of 2.35. The total field gradient calculated under the same conditions predicts a nuclear quadrupole moment Q in the range of 0.107-0.127 barns, which is smaller than the range predicted from the high spin ferric ion results. Reasons for the discrepancy are discussed. 16 references

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem