Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Comparative Study, English Abstract, Article, Arzneimittel-Forschung called Absorption studies with purines. Part 2: In vitro determination with the Resomat II using the Dibbern method, Author is Heppt-Becker, I.; Schunack, W., which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Safety of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.
By means of the Resomat II partition apparatus, the diffusion of 8 purines from artificial gastric or intestinal juice to artificial plasma across acetate and polyamide membranes was determined by the method of H. W. Dibbern and G. H. Scholz (1969), and the diffusion rate constants were calculated according to H. Stricker (1973). The drugs showed a proportional relation between diffusion rate and lipid solubility The effect of the different membranes on the model absorption results was studied, with and without applied alternating pressure. The results are compared with those of the Sartorius absorption model. Diffusion constants are given for each drug for absorption from gastric juice (pH 1.1) and intestinal juice (pH 7.0), and relations with drug structure are considered. The compounds studied were 1-hexyltheobromine [1028-33-7], 8-chlorotheophylline [85-18-7], theophylline (I) [58-55-9], caffeine (II) [58-08-2], pentoxifylline [6493-05-6], theobromine [83-67-0], proxyphylline [603-00-9], and diprophylline [479-18-5].
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem