Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Effect of methylxanthines on the concentration of gamma-aminobutyric acid in brain of normal and anoxic rats.Category: tetrahydrofurans.
In normal rats, caffeine (I) [58-08-2] (25 mg/kg, orally) increased cerebral GABA [56-12-2] concentration (41.3%) whereas pentifylline (II) [1028-33-7] (25 mg/kg, orally) diminished the concentration of GABA by 23.1%, the effects of similar concentrations of theophylline [58-55-9] and theobromine [83-67-0] were not significant. In anoxic rats, I and II caused a significant decrease in GABA concentration whereas theophylline increased GABA levels. Thus structurally similar methylxanthines have different effects on GABA concentrations in the brain.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem