Application In Synthesis of (2-Methylthiazol-4-yl)methanol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2-Methylthiazol-4-yl)methanol, is researched, Molecular C5H7NOS, CAS is 76632-23-0, about Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385. Author is Miller, John F.; Andrews, C. Webster; Brieger, Michael; Furfine, Eric S.; Hale, Michael R.; Hanlon, Mary H.; Hazen, Richard J.; Kaldor, Istvan; McLean, Ed W.; Reynolds, David; Sammond, Douglas M.; Spaltenstein, Andrew; Tung, Roger; Turner, Elizabeth M.; Xu, Robert X.; Sherrill, Ronald G..
A novel series of P1 modified HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and protease inhibitor-resistant viruses. Optimization of the P1 moiety resulted in compounds with femtomolar enzyme activities and cellular antiviral activities in the low nanomolar range culminating in the identification of clin. candidate GW0385.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem