The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (2-Methylthiazol-4-yl)methanol(SMILESS: OCC1=CSC(C)=N1,cas:76632-23-0) is researched.Recommanded Product: 16400-32-1. The article 《Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:76632-23-0).
N-Myristoyltransferase (NMT) represents a promising drug target within the parasitic protozoa Trypanosoma brucei (T. brucei), the causative agent for human African trypanosomiasis (HAT) or sleeping sickness. The authors have previously validated T. brucei NMT as a promising druggable target for the treatment of HAT in both stages 1 and 2 of the disease. The authors report on the use of the previously reported DDD85646 as a starting point for the design of a class of potent, brain penetrant inhibitors of T. brucei NMT.
Here is a brief introduction to this compound(76632-23-0)Category: tetrahydrofurans, if you want to know about other compounds related to this compound(76632-23-0), you can read my other articles.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem