The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Friedlander synthesis of highly functionalized isoxazolyl quinoline libraries via addition of C(sp3)-H bond to aldehydes, the main research direction is isoxazolyl quinoline preparation; dimethyl nitroisoxazole amino benzaldehyde ionic liquid Friedlander synthesis.Reference of 2-Amino-5-chlorobenzaldehyde.
A novel protocol for ionic liquid (IL)-mediated C(sp3)-H bond functionalization of 3,5-dimethyl-4-nitroisoxazoles to substituted o-aminobenzaldehydes was developed in excellent yields. Isoxazolyl aryl ethanones have been synthesized from isoxazolyl aryl ethanol synthon. Furthermore, the later was utilized as synthons for IL promoted Friedlander synthesis of highly functionalized isoxazole substituted quinoline libraries. The merit of this synthesis is easily available and economical starting materials, effective utilization of all the reactants, and simple workup procedure. It is noteworthy that ionic liquid used in C(sp3)-H bond functionalization and Friedlander synthesis reactions can be recycled and reused five times without significant decrease in activity.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem