So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dagenais, M.; Pomier-Layrargues, G.; Rocheleau, B.; Giroux, L.; Huet, P. M. researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Computed Properties of C13H20N4O2.They published the article 《Systemic and splanchnic hemodynamic effects of pentifylline in rats with portal hypertension》 about this compound( cas:1028-33-7 ) in Clinical Science. Keywords: pentifylline hemodynamics portal hypertension. We’ll tell you more about this compound (cas:1028-33-7).
The systemic and splanchnic hemodynamic effects of pentifylline (40 mg/kg body weight i.v.) were assessed in rats with portal hypertension associated either with CCl4-induced cirrhosis or portal vein ligation. Heparinized catheters were placed into the portal vein, inferior vena cava, aorta and left ventricle with exits from the neck. Hemodynamic studies were performed 4 h after consciousness was regained. Cardiac output and regional blood flows were measured using radiolabeled microspheres and the reference sample method in seven rats in each group; portal-systemic shunting was measured using microsphere injection in the ileo-colic vein in six rats in each group. Forty-five minutes after injection, pentifylline had no effect on mean arterial pressure, cardiac output, peripheral resistance, portal venous flow, hepatic artery flow or portal-systemic shunting in either group of rats with portal hypertension. The drug lowered portal pressure (-18%) in cirrhotic rats, but not in portal-vein-ligated rats. These data demonstrate that pentifylline lowers portal pressure in cirrhotic rats without affecting portal venous flow and portal-systemic shunting; this effect is possibly mediated by changes in intrahepatic resistance related to the effects of pentifylline on blood viscosity and/or on intrahepatic vasomotor tone.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem