When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. Synthetic Route of 165253-31-6
The present invention provides a 2 – nitro – 1, 3 – b [(tetrahydro – 3 – furyl) methyl] guanidine synthetic preparation method, in particular relates to a technical field of chemical synthesis, the (tetrahydro – 3 – furan) methylamine and O – methyl – N – nitro-isourea in saturated sodium chloride aqueous solution in the reaction, finally the resulting oily product is purified, by preparative high performance liquid chromatography separation and purification, to obtain 2 – nitro – 1, 3 – b [(tetrahydro – 3 – furyl) methyl] guanidine of the pure substance. The invention after HPLC – MS and 1 H NMR and 13 C NMR confirmation, purity of about 99.0%, thus can be applied to the report of the related impurities of GLP in qualitative and quantitative and economically feasible, the operation is simple, the universality is relatively strong, the yield is high. (by machine translation)
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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem