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Based on the most stable conformation of ZD6169, a series of N-arylated derivative of oxazolidindione (2), morpholin-3- one (3 5), piperidin-2-one (6), and pyrrolidin-2-one (7 13) was synthesized and evaluated for potassium channel opening activity. In the in-vitro assay , N-(4-benzoylphenyl)-piperidin-2-one (6) and N-(4-benzoylphenyl)-3,3-dimethyl-pyrrolidin-2-one (9) demonstrated potent and selective relaxant activity at the bladder detrusor muscle [IC50, bladder =7.4 and 6.7 muM, respectively; IC50 ratio (portal vein/bladder)=41 and 51, respectively]. Copyright
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 1679-47-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1679-47-6, in my other articles.
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem