Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. Application of 15833-61-1
Compounds having the formula STR1or a pharmaceutically acceptable salt thereof wherein R 1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L 2 –, and (i) heterocyclic-L 2 –; R 2 is selected from STR2(b) –C(O)NH–CH(R 14)–C(O)OR 15, STR3(d) –C(O)NH–CH(R 14)–C(O)NHSO 2 R 16, (e) –C(O)NH–CH(R 14)-tetrazolyl, (f) –C(O)NH-heterocyclic, and (g) –C(O)NH–CH(R 14)–C(O)NR 17 R 18 ; R 3 is heterocyclic, aryl, substituted or unsubstituted cycloalkyl; R 4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L 1 is absent or is selected from (a) –L 4 –N(R 5)–L 5 –, (b) –L 4 –O–L 5 –, (c) –L 4 –S(O) n –L 5 — (d) –L 4 –L 6 –C(W)–N(R 5)–L 5 –, (e) –L 4 –L 6 –S(O)m–N(R 5)–L 5 –, (f) –L 4 –N(R 5)–C(W)–L 7 –L 5 –, (g) –L 4 –N(R 5)–S(O) p –L 7 –L 5 –, (h) optionally substituted alkylene, (i) optionally substituted alkenylene, and (j) optionally substituted alkynylene are inhibitors of protein isoprenyl transferases. Also disclosed are protein isoprenyl transferase inhibiting compositions and a method of inhibiting protein isoprenyl transferases.
The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research.Keep reading other articles of 15833-61-1. Application of 15833-61-1
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem