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Introduction: More than 50% of the clinically established antibiotics are either genuine natural products or derivatives thereof, featuring a mode of action decisively depending on their metal affinity and suitability as metal complex ligands. As their structural diversity and harvest from renewable sources is well-nigh inexhaustible, any future quest for affordable new antibiotics will have to concentrate on natural drugs with obvious metal ligating properties. Areas covered: The authors provide an overview of the promising developments in the field of antibiotic natural products with metal-binding properties with a specific focus on metal binders such as polyphenols, quinones, 3-acyltetramic and -tetronic acids. Works published by the authors are discussed in this manuscript as well as articles derived from PubMed and Scifinder. Expert opinion: Natural products with metal-binding properties possess a great potential for the development of drugs against various bacteria. There are many derivatives with great potential against multidrug-resistant bacteria as well. Synthetic approaches to structurally complex and/or rare natural products have added significantly to the cracking of synthetic problems. Thus, this field of scientific research appears attractive both to chemists and to clinicians.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4971-56-6
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem