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A process for the oxidation of pantolactone to ketopantolactone comprises carrying out the oxidation with a periodate in the presence of a ruthenium catalyst, in an aqueous solvent system and in a microwave field. Ketopantolactone is a key intermediate in the manufacture of pantothenic acid, the latter being a member of the B complex vitamins and a constituent of coenzyme A. Asymmetric hydrogenation of ketopantolactone yields (D)(-)-pantolactone, from which pantothenic acid can then be manufactured.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.13031-04-4, you can also check out more blogs about13031-04-4
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem