Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. Application of 13031-04-4
Copper-catalyzed asymmetric direct alkynylation of alpha-ketoesters with terminal alkynes with chiral prolinol-phosphine ligands, most preferably (alphaR,2S)-1-(2-dicyclohexylphosphinobenzyl)-alpha-neopentyl-2-pyrrolidinemethanol, afforded various enantioenriched chiral propargylic tertiary alcohols. Quantum-chemical calculations using the BP86 density functional including Grimme’s empirical dispersion correction [DF-BP86-D3(BJ)-PCM(tBuOH)/TZVPP//DF-BP86-D3(BJ)/SVP] show the occurrence of OH?O/sp3-CH?O two-point hydrogen bonding between the chiral ligand and the carbonyl group of the ketoester in the stereo-determining transition states. Combined with the hydrogen-bonding interactions orienting the ketoester substrate, dispersive attractions between the chiral ligand (P-cyclohexyl groups) and the ketoester in the favored transition states, rather than steric repulsions in the disfavored transition state explain the enantioselectivity of the asymmetric copper catalysis.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 13031-04-4. Application of 13031-04-4
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem