The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, spectroscopic, and their interactions with reaction intermediates and transition states. Application of 87392-05-0
The invention belongs to the field of pharmaceutical chemicals and particularly relates to a synthetic method of R-(+)-sulfotetrahydrofuran-2-formic acid. The method solves the technical problem that the existing method is more in reaction steps and low in cost, needs high-toxicity and high-danger raw materials and is not environmentally friendly. The technical scheme solving the technical problem is that the invention provides the synthetic method of R-(+)-sulfotetrahydrofuran-2-formic acid which comprises the following steps: dissolving R-(+)-tetrahydrofuran-2-formic acid in an organic solvent; and then adding hydrogenated xanthogen and an organic alkali to react to obtain the R-(+)-sulfotetrahydrofuran-2-formic acid. The method is few in reaction step, free from high-toxicity and high-danger raw materials and environmentally friendly, and the yield is improved.
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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem