Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. Electric Literature of 149809-43-8
This invention discloses a process for preparing the formula 1 shown in the process for the preparation of posaconazole intermediate compound 1 method. Preparation method of the invention is compound have been reported in the literature for 2 as raw material, first of all three alkyl silicon-based protection of hydroxy to obtain compound 3, then with the triazole sodium salt of 4 reaction, to obtain compound 5, then in toluene sulfonyl chloride and alkali escapes the silicon ether and perform under the action of toluene sulfonyl protection to obtain compound 1. The invention can overcome the disadvantages of the prior art, and does not pass the splitting step, reduced side reaction occurs and impurity appear, improves the reaction selectivity and yield. (by machine translation)
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 149809-43-8. Electric Literature of 149809-43-8
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem