Day: August 19, 2021

Related Products of 165253-29-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 165253-29-2, Name is 3-(Bromomethyl)tetrahydrofuran,introducing its new discovery.

Compounds and compositions are presented that inhibit K-Ras, and especially mutant K-Ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 453-20-3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 453-20-3

The regioselectiv cleavage of unsymmetrical cyclic ethers provides a direct method of preparation of bi-and tri-functional molecules of synthetic interest.A variety of reagents have been utilized for this purpose, but many of them display a low level of regioselectivity.The combination of trialkylsilyl chlorides (R3SiCl) and sodium iodide (NaI) in acetonitrile was shown to be mild reagents for the ring opening of cyclic ethers and, for example, afforded 4-iodobutanol from tetrahydrofuran.However, no examples of cleavage of 2-substituted tetrahydrofurans with these reagents were reported.We report here the results concerning the ring opening of 1,2-epoxypropane, 2-ethyloxetane and 2-methyltetrahydrofuran by Me3SiCl or tBuMe2SiCl and NaI in CH3CN leading to iodoalcohols after hydrolysis.In all cases the formation of the primary iodide is preponderant and arises from complexation of the oxygen with the silyl group followed by the iodide ion attack at the less substituted carbon (SN2 type mechanism).In the case of Me3SiCl/NaI the observed regioselectivity increases from epoxide (86:14) to oxetane (91:9) and tetrahydrofuran (97:3).The tBuMe2SiCl/NaI gives about the same results.As expected the ring opening of 3-methyltetrahydrofuran is much less regioselective.When applied to tetrahydrofurfuryl alcohols the reaction with Me3SiCl/NaI in acetonitrile gives rise to the formation of iododiols, whereas in acetone the corresponding iodoacetonides are directly producted.A high degree of regioselectivity is observed even on the cleavage of 3-hydroxytetrahydrofuran (30:1) which, in the presence of acetone, is converted almost exclusively into the more thermodynamically stable iodoacetonide corresponding to 1,2-diol.Treatment of tetrahydrofurfuryl acetate and 3-acetoxytetrahydrofuran with Me3SiCl/NaI (two equivalents) in CH3CN afforded diiodoacetates.Thus, one obtains 2-acetoxy-1,5-diiodopentane from tetrahydrofurfuryl acetate and 2-acetoxy-1,4 diiodobutane from 3-acetoxytetrahydrofuran respectively.These products result from the cleavage of the silyl ether intermediate with 1,2 migration of the acetoxy group in the first case and without migration in the second.The proposed mechanism involves the formation of acyloxonium ion, the attack on which from the less hindered side by an iodide ion leads to the above mentioned products.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of 2144-40-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2144-40-3, Name is (cis-Tetrahydrofuran-2,5-diyl)dimethanol, molecular formula is C6H12O3. In a Article，once mentioned of 2144-40-3

1,6-Hexanediol (1,6-HDO) was effectively prepared from 5-hydroxymethylfurfural (HMF) over double-layered catalysts of Pd/SiO2 + Ir-ReOx/SiO2 in a fixed-bed reactor. Under optimal reaction conditions (373 K, 7.0 MPa H2, in solvent mixtures of 40% water and 60% tetrahydrofuran (THF)), 57.8% yield of 1,6-HDO was obtained. The double-layered catalysts loaded in double-layered beds showed much superior performance compared to that of a single catalyst of Pd-Ir-ReOx/SiO2, even when the same amount of active components were used in the catalysts. The reaction solvent significantly affected product distributions, giving a volcano-shape plot for the 1,6-HDO yield as a function of the ratio of water to THF. Br°nsted acidic sites were generated on the catalyst in the presence of water which played determining roles in 1,6-HDO formation. A high pressure of H2 contributed to 1,6-HDO formation by depressing the over-hydrogenolysis of reaction intermediates and products to form hexane and hexanol. The reaction route was proposed for HMF conversion to 1,6-HDO on the basis of conditional experiments.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

4971-56-6, Name is Furan-2,4(3H,5H)-dione, belongs to tetrahydrofurans compound, is a common compound. Formula: C4H4O3In an article, once mentioned the new application about 4971-56-6.

4-Methyleneoxetan-2-one (Diketene or DK) consists of a four-membered lactone ring adjacent to a methylene function. It can be used as a versatile precursor for the syntheses of wide range of heterocycles including fused and spiral biheterocycles. In this chapter, we try to cover the structural features and reactivity of DK, and underscore its applications as a flexible and useful synthon in the syntheses of four- and five-membered heterocycles as well as a wide variety of fused or spiro heterocycles. This chapter as part 1 is divided in accordance with the ring sizes and subdivided according to types, numbers, and arrangements of heteroatoms.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 105-21-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.105-21-5, Name is Gamma-heptalactone, molecular formula is C7H12O2. In a Article，once mentioned of 105-21-5

The study of the volatile components presents in the headspace of 27 sunflower oil samples, stored over different periods of time, at room temperature in closed receptacles, in presence of limited amounts of air, has been carried out by solid phase microextraction (SPME) followed by gas chromatography/mass spectrometry (GC/MS). The composition of the headspace of the studied samples is highly varied, ranging from the characteristic of non-oxidized oils to that of oils with a high oxidation level. Among the detected compounds are alkanals, (E)-2-alkenals, 2,4-alkadienals, ketones, acids, esters, alcohols, as well as aliphatic and aromatic hydrocarbons. In samples having a certain oxidation degree it is worth noting the presence of a significant number of genotoxic and cytotoxic oxygenated alpha,beta-unsaturated aldehydes (OalphabetaUAlphas), such as 4-hydroxy-2-nonenal, 4-oxo-2-nonenal or 4,5-epoxy-2-decenal, which have been considered responsible for various degenerative diseases which are widespread nowadays; some of these compounds are described in this manuscript for the first time as coming from edible oil oxidation at room temperature. In addition, it has been found the occurrence of polycyclic aromatic hydrocarbons (PAHs) in concentrations in line with the oxidation level of the sample.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 4,4-Dimethyldihydrofuran-2,3-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione, molecular formula is C6H8O3

Rhodium nanoparticles were successfully stabilized by the (S,S)-1,2-ethanediylbis[(2-ethoxyphenyl)phenylphosphine] ((S,S)-DIPAMP) deposited on SiO2 prepared by a facile reduction and impregnation method. The chiral catalysts obtained were efficient for the enantioselective hydrogenation reactions of prochiral compounds. The catalysts synthesized from [Rh(?-OMe)(COD)]2 in the presence of different amounts of a ligand used as chiral stabilizer, showed good metal dispersion. As shown by TEM, the metal particle size ranged between 1 and 2 nm using stabilizer and 9.1 nm was achieved without chiral ligand. Other techniques were used to characterize the chiral catalysts such as X-ray diffraction (XRD), electron diffraction, thermogravimetric analysis (TGA) and N2 adsorption-desorption isotherms. (S,S)-DIPAMP was used as the stabilizer of metal particles to prevent growing and agglomeration, and it also acts as chiral modifier inducing enantioselectivity in the asymmetric hydrogenation of 3,4-hexanodione (HD), ethyl pyruvate (EP), ketopantolactone (KP), and acetophenone (AP). Under specific conditions such as 25 C, 40 bar of H2 and substrate/Rh=100, 1%Rh-(S,S)-DIPAMP/SiO2 chiral catalysts showed excellent catalytic performance with conversion and enantiomeric excess (ee) levels up to 99% and 54% respectively.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 13031-04-4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 13031-04-4, in my other articles.

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C6H12O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 2144-40-3, Name is (cis-Tetrahydrofuran-2,5-diyl)dimethanol, molecular formula is C6H12O3

Currently, highly efficient transformation of abundant and low-cost renewable raw biomass into high-quality biofuels and important chemicals is one of the most promising solutions to the current energy crisis, rapid consumption of fossil resources, increasing emission of greenhouse gases and serious environmental pollution. Here, convertible production of promising 2,5-dimethylfuran (DMF) and 2,5-dimethyltetrahydrofuran (DMTHF) biofuels was achieved successfully via green catalytic transfer hydrogenolysis of biomass-derived 5-hydroxymethylfurfural (HMF) using a nitrogen-doped carbon (NC)-decorated copper-based catalyst with cyclohexanol as hydrogen source. DMF or DMTHF with high yield of 96.1% or 94.6% was produced convertibly through simply modulating reaction time. Extensive characterizations revealed that appropriate surface base sites on the catalyst could efficiently promote the activation of alcohol hydroxyl in cyclohexanol and the subsequent release of active hydrogen species, while highly dispersed surface Cu0 nanoparticles and electrophilic Cu+ species were beneficial to the hydrogen transfer and the activation of both the carbonyl group and the hydroxyl group in HMF, respectively. Moreover, as-fabricated NC-decorated Cu-based catalyst presented high stability without obvious loss of catalytic performance after five consecutive cycles, due to the strong interaction between the support and active metal species. Such non-noble metal catalyst has a promising industrial application in the production of valuable biomass fuels.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C6H12O3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2144-40-3, in my other articles.

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 22929-52-8, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 22929-52-8, name is Dihydrofuran-3(2H)-one. In an article，Which mentioned a new discovery about 22929-52-8

A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has applicability as a therapeutic agent for cognitive dysfunctions in Alzheimer’s disease. wherein R1 is a hydrogen atom; R2 is an aromatic ring group, etc.; R3 is a hydrogen atom, etc; R4 is a hydrogen atom; R5 is an oxepanyl group, etc.; R6 is a hydrogen atom.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of 87392-05-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 87392-05-0, molcular formula is C5H8O3, introducing its new discovery.

The invention provides novel compounds having the general formula (I) wherein X1 is N or N+O-, and one of X2, X3 and X4 is N or N+-O- and the remainder of X2, X3 and X4 is C. R2, R3, R4, R5, R6. A, B and Y are as described herein. Additionally compositions compounds of Formula (I) and methods of use are further described herein.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 87392-05-0 is helpful to your research. Electric Literature of 87392-05-0

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 4100-80-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, molecular formula is C5H6O3. In a Patent，once mentioned of 4100-80-5

(Meth) acrylic acid ester of [be] hydrophobic properties. (1) (Meth) acrylic ester represented by the formula [a]. R1 Is H or methyl; R3 Alkyl, cycloalkyl, aryl or aralkyl; R21 , R22 , R23 Each independently is H, alkyl or cycloalkyl is not one of at least 2 H; Z1 The divalent chain hydrocarbon substituted of unsubstituted C1 a-20/2, 2 // hetero-substituted of unsubstituted C1 a-20 free of divalent cyclic hydrocarbon or a single bond; Z2 The divalent chain hydrocarbon of C1 c 12 2, Z3 The (R21 R22 R23 ) Coupled with a free cyclic hydrocarbon containing heteroatoms C C – C3 d 10/forming atomic group; n is an integer of 0 – 3; m is an integer of 1 – 18[Drawing] no (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4100-80-5

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem