Electric Literature of 4971-56-6, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Data Paper, and a compound is mentioned, 4971-56-6, Furan-2,4(3H,5H)-dione, introducing its new discovery.
We present a modern in silico virtual screening workflow towards novel MurB inhibitors. Namely, the field of antibacterial research is in crucial need of novel lead compounds on new or underexplored therapeutic targets such as MurB. We identified three structurally distinct compounds that indicated promising micromolar inhibitory activity on E. coli MurB. All three compounds did not display cytotoxicity on HepG2 cell line, but also did not possess in vitro antimicrobial activity against S. aureus and E. coli. After the second biological evaluation using radio-labelled substrates in a MurA-MurB coupled test, only marginal inhibitory potency could be reproduced on MurB. As no compound in the series was able to significantly decrease the residual activity of the enzyme, we decided to report the complete inactive compound set to be used as decoys.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 4971-56-6. In my other articles, you can also check out more blogs about 4971-56-6
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem