A new application about Furan-2,4(3H,5H)-dione

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Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of Furan-2,4(3H,5H)-dione, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 4971-56-6

The catalyst-free domino reaction of ethyl 4-hydroxyalkyl-2-ynoate and N-heteroaryl-methyl-N-2, 2-difluoroethan-1-amine was developed, and used to synthesize 4-(N-(2, 2-difluoroethyl)(N-heteroarylmethyl)amino)-5, 5-disubstitutedfuran-2(5H)-one in methanol under the reflux condition with yields of 39%~83%. Their structures were characterized by 1H NMR, 13C NMR, and HR-ESI-MS data, further confirmed by the X-ray crystal diffraction of 3-chloro-4-((N-2, 2-difluoroethyl)(N-pyrimidin-5-ylmethyl)amino)-5, 5-spiro(4-methoxycyclohexyl)furan-2(5H)-one (8). The bioassay results showed that 4-((N-2, 2-difluoroethyl)(N-6-chloropyridin-3-ylmethyl)amino)-5, 5-dimethylfuran-2(5H)-one (3a) and 4-((N-2, 2-difluoroethyl)(N-6-fluoropyridin-3-ylmethyl)-amino)-5, 5-dimethylfuran-2(5H)-one (3c) exhibit 100% mortality against Myzus persicae at the concentration of 600 mug?mL-1, respectively.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem