Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 21461-84-7. Introducing a new discovery about 21461-84-7, Name is (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid
The invention relates to a preparation method of a Bruton’s tyrosine kinase (Btk) intermediate (VI). The method comprises the following steps: carrying out benzylamine ring opening on a compound (S)-(+)-5-substituted-2-tetrahydrofurancarboxylic acid to obtain a product, and reacting the product with acyl chloride or acid anhydride to obtain a compound II; reducing the compound II, carrying out salt formation on the reduced compound II by using 1R-(-)-camphorsulfonic acid, and degrading the obtained salt to obtain a compound III; and reducing the compound III, carrying out salt formation on the reduced compound III and AcOH to obtain a compound V, and carrying out Boc addition on the compound V under an alkaline condition to obtain the target compound VI.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid, you can also check out more blogs about21461-84-7
Referenceï¼?br>Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem