One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C5H10O2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 57203-01-7, Name is (S)-(Tetrahydrofuran-2-yl)methanol, molecular formula is C5H10O2
Naftidrofuryl oxalate (Praxilene, 1) has been used for the treatment of intermittent claudication for more than 30 years. It selectively blocks vascular and platelet 5-hydroxytryptamine 2 (5-HT2) receptors. This drug is marketed as a mixture of four stereoisomers, and so far there is no individual biological evaluation on the single isomers. The purpose of this study is to provide an improved method for the preparation of all four stereoisomers of naftidrofuryl, and more importantly, to distinguish them in terms of their binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor. The bioassay results revealed that the C-2S configuration of naftidrofuryl was crucial for the binding affinity with 5-HT2A receptor, and the C-2? configuration was less important for binding. In conclusion, our study may pave the way to develop single naftidrofuryl isomers with C-2S configuration as inhibitors of 5-HT2A receptor that have clinical significance as vasodilators and CNS agents.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of (S)-(Tetrahydrofuran-2-yl)methanol, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 57203-01-7, in my other articles.
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem