Properties and Exciting Facts About (S)-(Tetrahydrofuran-2-yl)methanamine

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Enantiopure bis(mu-acetato)-bridged planar chiral cyclopalladated products [Pd{(eta5-C5H3-CR=NCH2CHCH 2CH2CH2O)Fe(eta5-C 5H5)}(mu-OAc)]2 (R = H, Me) have been obtained by asymmetric cyclopalladation of the corresponding chiral ferrocenylimines with palladium-(II) acetate and sodium acetate in methanol at room temperature with a high level of diastereoselectivity (product ratio syn-(+)-(Rp,R,R,Rp):syn-(-)-(Sp,R,R,S p) ? syn-(-)-(Sp,S,S,Sp): syn-(+)-(Rp,S,S,Rp) ? 9:1). One or both acetato groups can be readily substituted by other anionic ligands to yield novel mixed-bridge or bis(mu-anion)-bridged planar chiral dimers of ferrocene derivatives. The first cis-type syn-(Rp,Sp) cyclopalladated dimer of ferrocenylimine has been obtained. The diphenylacetylene insertion reaction of a variety of anion-bridged planar chiral dimeric cyclopalladated derivatives of ferrocene has also been investigated. The absolute configurations of bis(mu-acetato)-, bis(mu-halogeno)-, (mu-1kappaS:2kappaN)-(mu-1kappaN:2kappaS)-thiocyanato-, and (mu-1kappaO:2kappaN)-(mu-1kappaN:2kappaO)-nitrito-bridged planar chiral dimers and bis-(diphenylacetylene) insertion products have been elucidated by single-crystal X-ray analysis.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem