Electric Literature of 1679-47-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1679-47-6, Name is 3-Methyldihydrofuran-2(3H)-one,introducing its new discovery.
The asymmetric hydroxylation of the enolates of fully substituted acyclic ester 8 and lactone 10 with (camphorylsulfonyl)oxaziridines 1a – c was studied.The stereoselectivities of the tertiary alpha-hydroxy carbonyl products were highly dependent on the enolate structure, the oxidizing reagents, and the reaction conditions.While high diastereoselectivity (up to 94percent) was obtained for enolates of fully substituted menthol ester 8 with substoichiometric amounts of oxaziridine 1a, the yields were unsatisfactory.On the other hand, the enantioselective alpha-hydroxylation of the sodium enolate of 2-methyl-gamma-butyrolactone (10) with <(8,8-dimethoxycamphoryl)sulfonyl>oxaziridine (1c) afforded alpha-hydroxy lactone 11a in 70percent yield and 84percent ee.The enantiomeric excess was improved to >93percent ee by crystallization of the corresponding benzoyl ester 11c.The utility of both enantiomers of 11c were demonstrated in the formal asymmetric syntheses of the pheromone, (1S,5R)-(-)-frontalin (13) and in the asymmetric synthesis of (R)-(-)-mevalonolactone (20).
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1679-47-6, and how the biochemistry of the body works.Electric Literature of 1679-47-6
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem