Can You Really Do Chemisty Experiments About Furan-2,4(3H,5H)-dione

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of Furan-2,4(3H,5H)-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3

A series of novel 3-acetyl-4-hydrazinyl-5,5-disubstitutedtetronic acid and (E/Z)-3-(1-hydrazinylethyli-dene)-5,5-disubstitutedfuran-2,4-dione derivatives were designed and synthesized, and four methyl 5-methyl pyrazole-4-carboxylate were obtained unexpectedly. Their structures were confirmed by high-resolution mass spectrum (HR-ESI-MS), 1H NMR, 13C NMR spectral data and X-ray diffraction. The bioassay results of the hydrazinyl compounds along with the amino analogues indicated that some compounds exhibited moderate to excellent fungicidal activities against phytopathagens. For example, compounds 5G, 5H, 5I and 5i showed 100% in vivo control efficacy against Colletotrichum lagenarium, and compound 5G also exhibited 100% in vivo control efficacy against Erysiphe graminis, Puccinia polysora and Colletotrichum lagenarium at 400 mug/mL. Compounds 5b, 5E and 6F showed 100% mortality against Plutella xylostella, compounds 6A, 6g and 6H exhibited 100% mortality against Myzus persicae, and compound 6b showed 100% mortality against Tetranychus cinnabarinus at 600 mug/mL. The 5,5-spiro cyclohexyl moiety significantly improved the fungicidal activity of the tetronic acid derivatives, and the introduction of the substituted hydrazino group to the furan-2,4-dione skeleton led to higher insecticidal and acaricidal activities. 5G and 5i were found to have the most potential to be further modified for searching new fungicide as the lead compounds.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem