Archives for Chemistry Experiments of Furan-2,4(3H,5H)-dione

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Infrared and FT-Raman spectra of both deuterated and undeuterated tetronic acid have been examined.The enol form predominates in the solid form, but some keto form is apparent in the spectra.Reported here are the tentative assignments for all bands observed from 4000 to 200 cm-1.Group frequencies obtained by comparing the spectral data acquired with vibrational assignments of similar compounds by other investigators were used to aid the assignment.The spectra are consistent with CS point group, indicating the structure of tetronic acid to be planar in the solid state.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extracurricular laboratory:new discovery of 111769-27-8

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 111769-27-8, name is (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate, introducing its new discovery. Product Details of 111769-27-8

A class of potent, nonsteroidal, selective indazole ether-based glucocorticoid receptor modulators (SGRMs) was developed for the inhaled treatment of respiratory diseases. Starting from an orally available compound with demonstrated anti-inflammatory activity in rat, a soft-drug strategy was implemented to ensure rapid elimination of drug candidates to minimize systemic GR activation. The first clinical candidate 1b (AZD5423) displayed a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation combined with a moderate systemic GR-effect, assessed as thymic involution. Further optimization of inhaled drug properties provided a second, equally potent, candidate, 15m (AZD7594), that demonstrated an improved therapeutic ratio over the benchmark inhaled corticosteroid 3 (fluticasone propionate) and prolonged the inhibition of lung edema, indicating potential for once-daily treatment.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Can You Really Do Chemisty Experiments About (R)-Tetrahydrofuran-3-carboxylic acid

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Disclosed herein, inter alia, are compositions and methods for modulating Adenosine Receptors. In an aspect is provided a method of inhibiting Adenosine A2B Receptor activity and Adenosine A2A Receptor activity, the method including contacting the Adenosine A2B Receptor and Adenosine A2A Receptor with a compound as described herein, including embodiments.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 52079-23-9

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Application of 52079-23-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 52079-23-9, Name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone, molecular formula is C4H6O3. In a Patent,once mentioned of 52079-23-9

The invention relates to a process for the preparation of optically active alcohols from optically active carboxylic acids by reducing an optically active carboxylic acid with hydrogen in the presence of a catalyst comprising ruthenium and at least one further metal or transition metal having an atomic number in the range of from 23 to 82.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Can You Really Do Chemisty Experiments About Furan-2,4(3H,5H)-dione

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of Furan-2,4(3H,5H)-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3

A series of novel 3-acetyl-4-hydrazinyl-5,5-disubstitutedtetronic acid and (E/Z)-3-(1-hydrazinylethyli-dene)-5,5-disubstitutedfuran-2,4-dione derivatives were designed and synthesized, and four methyl 5-methyl pyrazole-4-carboxylate were obtained unexpectedly. Their structures were confirmed by high-resolution mass spectrum (HR-ESI-MS), 1H NMR, 13C NMR spectral data and X-ray diffraction. The bioassay results of the hydrazinyl compounds along with the amino analogues indicated that some compounds exhibited moderate to excellent fungicidal activities against phytopathagens. For example, compounds 5G, 5H, 5I and 5i showed 100% in vivo control efficacy against Colletotrichum lagenarium, and compound 5G also exhibited 100% in vivo control efficacy against Erysiphe graminis, Puccinia polysora and Colletotrichum lagenarium at 400 mug/mL. Compounds 5b, 5E and 6F showed 100% mortality against Plutella xylostella, compounds 6A, 6g and 6H exhibited 100% mortality against Myzus persicae, and compound 6b showed 100% mortality against Tetranychus cinnabarinus at 600 mug/mL. The 5,5-spiro cyclohexyl moiety significantly improved the fungicidal activity of the tetronic acid derivatives, and the introduction of the substituted hydrazino group to the furan-2,4-dione skeleton led to higher insecticidal and acaricidal activities. 5G and 5i were found to have the most potential to be further modified for searching new fungicide as the lead compounds.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

New explortion of (Tetrahydrofuran-3-yl)methanol

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Application of 15833-61-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol, molecular formula is C5H10O2. In a article,once mentioned of 15833-61-1

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and R1, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of (S)-(-)-alpha-Hydroxy-gamma-butyrolactone

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Synthetic Route of 52079-23-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 52079-23-9, Name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone,introducing its new discovery.

Compounds of the pregnane series are described having general formula (I) or their solvates in which R1 individually represents –OC(=O)C1-6 alkyl; R2 individually represents hydrogen, methyl (which may be in the alpha or beta configuration) or methylene; or R1 and R2 together represent formula (a) where R5 and R6 are the same or different and each represents hydrogen or C1-6 alkyl; R3 and R4 are the same or different and each represents hydrogen or halogen; and represents a single or a double bond. Compounds of formula (I) and their solvates are useful as anti-inflammatory or anti-allergic agents. STR1

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The Absolute Best Science Experiment for (S)-4-Hydroxydihydrofuran-2(3H)-one

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. HPLC of Formula: C4H6O3. Introducing a new discovery about 7331-52-4, Name is (S)-4-Hydroxydihydrofuran-2(3H)-one

The mechanism of fast pyrolysis of cellulose has been studied by using an analytical pyrolyzer coupled with a gas chromatography-mass spectrometry set-up (Py-GC/MS). The results showed that the main products comprised pyrans such as levoglucosan and levoglucosenone, furans such as furfural and 5-hydroxymethyl furfural, and linear small molecular chemicals such as acetaldehyde and 1-hydroxy-2-propanone. The compositions of products from fast pyrolysis of cellubiose and glucose were similar to that from cellulose, but with higher furan contents and lower pyran contents. Based on the experimental results, density functional theory (DFT) studies were carried out to deduce the pyrolysis mechanism of cellulose. The results showed the formation of 5-hydroxymethyl furfural from d-glucopyranose unit to be easier than the formation of levoglucosan, in agreement with the experimental results. The deduced mechanism of reaction pathways in cellulose pyrolysis provides insight into the pyrolysis behavior of cellulose and allows modification of previously proposed related mechanisms.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about 3-Hydroxytetrahydrofuran

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A transition-metal-free protocol capable of synthesizing diarylated aniline derivatives is reported. This method could be further employed to prepare aryl alkyl ethers. A wide range of thioethers, anilines, as well as alcohols were tolerated thanks to the mild reaction conditions. The strength of our method was demonstrated by performing a gram-scale reaction (20 mmol) followed by conversion of the nitrile group into synthetically useful aldehyde, ketone, and carboxylic acid.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

More research is needed about 3-Methyldihydrofuran-2,5-dione

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4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, belongs to tetrahydrofurans compound, is a common compound. Recommanded Product: 3-Methyldihydrofuran-2,5-dioneIn an article, once mentioned the new application about 4100-80-5.

Ruthenium nanoparticles supported on titania are over three times more active than conventional ruthenium on carbon for the hydrogenation of lactic acid. This superior catalytic activity can be due to a combined action of small ruthenium nanoparticles and the titania support.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem